Response to teriparatide in patients with baseline 25-hydroxyvitamin D insufficiency or sufficiency.

CONTEXT Serum 25-hydroxyvitamin D (25OHD) concentrations greater than 30 ng/ml have been recommended for lowering fracture risk. OBJECTIVE Our objective was to determine whether 25OHD sufficiency is a prerequisite for effective response to teriparatide (TPTD). DESIGN AND PATIENTS Data were from 1620 osteoporotic postmenopausal women in the Fracture Prevention Trial. The response to TPTD was assessed in women subgrouped by having 25OHD insufficiency (>10 but 30 but 0.10). However, it should be noted that because of the limited number of fractures, this study does not exclude the possibility of differences in fracture outcome between the subgroups. CONCLUSIONS In postmenopausal women with osteoporosis and normal intact PTH, the responses to TPTD did not differ significantly in women with baseline 25OHD insufficiency or sufficiency.